Biochem/physiol Actions
Primary TargetD3
General description
A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther.314, 310.Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther.294, 1154.
Packaging
5 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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